The importance of HLA for the development of cell therapies

Eisenberg is proud to partner with PromoCell, a leading supplier of human primary cells, cell culture media, and reagents for life science research.

Thanks to a greater understanding of Human Leukocyte Antigen (HLA) function, researchers can now work toward developing new cancer immunotherapies.

HLA genes encode for glycoproteins present on the cell membrane. They bind peptides or antigens in ‘peptide binding grooves’ and present these to cells of the immune system. The HLA-type helps the immune system to identify the cells of the body. HLA also plays an important role in infectious diseases (host response to foreign pathogens), in transplantation and rejection of transplanted tissue, in autoimmunity, and cancer.

The applications for HLA typed cells are:

  • Tumor Immunology – e.g. identifying tumor antigens or develop T Cell Receptor (TCR) therapy
  • Biomarkers to understand how patients respond to certain cancer therapies
  • Drug & vaccines development for different diseases (e.g. autoimmune disease)
  • Understanding immune responses

Find more information on how PromoCell’s HLA typing service supports your research and development efforts visit PromoCell’s webpage about HLA-Typed Human Primary Cells.

For further information please contact Shlomi at: shlomi.levy@eb1.co.il